Longitudinal perspective on the conundrum of central arterial stiffness, blood pressure, and aging.
نویسندگان
چکیده
The age-associated increase in arterial stiffness has long been considered to parallel or to cause the age-associated increase in blood pressure (BP). Yet, the rates at which pulse wave velocity (PWV), a measure of arterial stiffness, and BP trajectories change over time within individuals who differ by age and sex have not been assessed and compared. This study determined the evolution of BP and aortic PWV trajectories during a 9.4-year follow-up in >4000 community-dwelling men and women of 20 to 100 years of age at entry into the SardiNIA Study. Linear mixed effects model analyses revealed that PWV accelerates with time during the observation period, at about the same rate over the entire age range in both men and women. In men, the longitudinal rate at which BP changed over time, however, did not generally parallel that of PWV acceleration: at ages>40 years the rates of change in systolic BP (SBP) and pulse pressure (PP) increase plateaued and then declined so that SBP, itself, also declined at older ages, whereas PP plateaued. In women, SBP, diastolic BP, and mean BP increased at constant rates across all ages, producing an increasing rate of increase in PP. Therefore, increased aortic stiffness is implicated in the age-associated increase in SBP and PP. These findings indicate that PWV is not a surrogate for BP and that arterial properties other than arterial wall stiffness that vary by age and sex also modulate the BP trajectories during aging and lead to the dissociation of PWV, PP, and SBP trajectories in men.
منابع مشابه
Presentation of a Non-invasive Method of Estimating Arterial Stiffness by Modeling Blood Flow and Arterial Wall Based on the Determination of Elastic Module of Arterial Wall
Introduction: Arterial stiffness is an important predictor of cardiovascular risk. Several indices have been introduced to estimate the arterial stiffness based on the changes in the brachial blood pressure. Since the substitution of the blood pressure changes in the central arteries such as carotid with the blood pressure changes in the brachial results in error in the blood...
متن کاملبرآورد سرعت موج پالس با استفاده از پارامترهای شریانی استخراج شده از تصاویر فراصوتی کاروتید
Background & Objective : Several indices have been introduced to estimate arterial stiffness that based on changes in brachial blood pressure. But because of the error resulted by the substitution of brachial blood pressure instead of the other central arteries, such as carotid, it will be very important to present elastic parameter based on the mechanical models without any emphasis on brach...
متن کاملLongitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging.
Carotid-femoral pulse wave velocity (PWV), a marker of arterial stiffness, is an established independent cardiovascular risk factor. Little information is available on the pattern and determinants of the longitudinal change in PWV with aging. Such information is crucial to elucidating mechanisms underlying arterial stiffness and the design of interventions to retard it. Between 1988 and 2013, w...
متن کاملHemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA).
An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into increased brachial and central systolic blood pressu...
متن کاملAortic Stiffening, Aortic Blood Flow Reversal, and Renal Blood Flow.
N ormal arterial aging is characterized by arterial enlargement , wall thickening, and stiffening, which predominates at large arteries. 1 Patients with chronic kidney disease (CKD) have an early vascular aging, 2 characterized by an accelerated arterial enlargement and stiffening, which occurs in parallel with the decline in glomerular filtration rate (GFR). 3 The relationships between central...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Hypertension
دوره 64 6 شماره
صفحات -
تاریخ انتشار 2014